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複合薬物解析学研究室

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論文

  • 2022年
  • Araki R, Nishida S, Oishi Y, Tachioka H, Kita A, Yabe T.
    Methyl Donor Supplementation Prevents a Folate Deficiency-induced Depression-like State and Neuronal Immaturity of the Dentate Gyrus in Mice.
    Neuroscience.,485,12-22,2022.
  • 2021年
  • Araki R, Tachioka H, Kita A, Fujiwara H, Toume K, Matsumoto K, Yabe T.
    Kihito prevents corticosterone-induced brain dysfunctions in mice.
    J Tradit Complement Med.,11(6),513-519,2021.
  • Araki R, Nishida S, Nakajima Y, Iwakumo A, Tachioka H, Kita A, Yabe T.
    Low folate induces abnormal neuronal maturation and DNA hypomethylation of neuronal differentiation-related genes in cultured mouse neural stem and progenitor cells.
    Heliyon.,7(9),e08071,2021.
  • Araki R, Yasubuchi A, Ikegaya M, Hojo C, Tachioka H, Kawai K, Omote M, Kita A, Yabe T.
    Ferulic acid alleviates abnormal behaviors in isolation-reared mice via 5-HT1A receptor partial agonist activity.
    Psychopharmacology (Berl).,238(8),2147-2154,2021.
  • 2020年
  • Nishida S, Araki R, Baba A, Asari S, Tachibana S, Nakajima Y, Iwakumo A, Yabe T.
    Post-weaning folate deficiency induces a depression-like state via neuronal immaturity of the dentate gyrus in mice.
    J Pharmacol Sci.,143(2),97-105,2020.
  • 2019年
  • Matsumoto K, Fujiwara H, Araki R, Yabe T.
    Post-weaning social isolation of mice: A putative animal model of developmental disorders.
    J Pharmacol Sci.,141(3),111-118,2019.
  • Guo Q, Ebihara K, Fujiwara H, Toume K, Awale S, Araki R, Yabe T, Dong E, Matsumoto K.
    Kami-shoyo-san ameliorates sociability deficits in ovariectomized mice, a putative female model of autism spectrum disorder, via facilitating dopamine D1 and GABAA receptor functions.
    J Ethnopharmacol.,236,231-239,2019.
  • Guo QY, Ebihara K, Shimodaira T, Fujiwara H, Toume K, Dibwe DF, Awale S, Araki R, Yabe T, Matsumoto K.
    Kami-shoyo-san improves ASD-like behaviors caused by decreasing allopregnanolone biosynthesis in an SKF mouse model of autism.
    PLoS One.,14(1),e0211266,2019.
  • Hiraki Y, Araki R, Fujiwara H, Ago Y, Tanaka T, Toume K, Matsumoto K, Yabe T.
    Kamiuntanto increases prefrontal extracellular serotonin levels and ameliorates depression-like behaviors in mice.
    J Pharmacol Sci.,139(2),72-76,2019.
  • 2018年
  • Araki R, Fujiwara H, Matsumoto K, Toume K, Yabe T.
    Polygalae Radix extract ameliorates behavioral and neuromorphological abnormalities in mice treated chronically with corticosterone.
    Tradit Kampo Med.,5,89-97,2018.
  • 2017年
  • Fujiwara H, Tsushima R, Okada R, Awale S, Araki R, Yabe T, Matsumoto K.
    Sansoninto, a traditional herbal medicine, ameliorates behavioral abnormalities and down-regulation of early growth response-1 expression in mice exposed to social isolation stress.
    J Tradit Complement Med.,8(1),81-88,2017.
  • Ebihara K, Fujiwara H, Awale S, Dibwe DF, Araki R, Yabe T, Matsumoto K.
    Decrease in endogenous brain allopregnanolone induces autism spectrum disorder (ASD)-like behavior in mice: A novel animal model of ASD.
    Behav Brain Res.,334,6-15,2017.
  • Fujiwara H, Han Y, Ebihara K, Awale S, Araki R, Yabe T, Matsumoto K.
    Daily administration of yokukansan and keishito prevents social isolation-induced behavioral abnormalities and down-regulation of phosphorylation of neuroplasticity-related signaling molecules in mice.
    BMC Complement Altern Med.,17(1),195,2017.
  • 2016年
  • Araki R,Hiraki Y,Nishida S,Inatomi Y,Yabe T.
    Gomisin N ameliorates lipopolysaccharide-induced depressive-like behaviors by attenuating inflammation in the hypothalamic paraventricular nucleus and central nucleus of the amygdala in mice.
    J Pharmacol Sci.,in press.,132(2),138-144,2016.
  • Araki R,Yabe T.
    [Involvement of dorsal raphe GABAB receptors in abnormal responses to social stimulation in isolation-reared mice].「隔離飼育が引き起こす社会刺激に対する応答異常と背側縫線核のGABA
    B受容体との関連性」
    Nihon Yakurigaku Zasshi.日薬理誌(Folia Pharmacol.Jpn.),147(4),219-224,2016.
  • Araki R, Nishida S, Hiraki Y, Feng Li, Matsumoto K, Yabe T;
    Kamikihito ameliorates lipopolysaccharide-induced sickness behavor via attenuating neural activation but not inflammation in the hypothalamic paraventricular nucleus and the central nucleus of the amygdala in mice.
    Biol Pharm Bull.,39(2),289-294,2016.
  • Araki R, Hiraki Y, Nishida S, Kuramoto N, Matsumoto K, Yabe T;
    Epigenetic regulation of dorsal raphe GABAB1A associated with isolation-induced abnormal responses to social stimulation in mice.
    Neuropharmacology, 101,1-12,2016
    .
  • 2015年
  • Araki R, Nishida S, Matsumoto K, Yabe T;
    DNA methylation of the GC box in the promoter region mediates isolation rearing-induced suppression of srd5al transcription in the prefrontal cortex.
    Neurosci Lett.,299,124-145,2015.
  • Araki R, Nishida S, Hiraki Y, Yabe T;
    Kamikihito ameliiorates tumor-induced sickness behavor in mice.
    Traditional & Kampo medicine,2,93-96,2015.
  • Okada R, Fujiwara H, Mizuki D, Araki R, Yabe T, Matsumoto K;
    Involvement of dopaminergic and cholinergic systems in social isolation-induced deficits in social affiliation and conditional fear memory in mice.
    Neuroscience,299,124-145,2015.
  • 2014年
  • Araki R, Hiraki Y, Yabe T;
    Genipin attenuates lipopolysaccharide-induced persistent changes of emotional behavors and neural activation in the hypothalamic paraventricular nucleus and the central amygdala nucleus.
    Eur.J.Pharmacol.,741,1-7,2014.
  • 2013年
  • Araki R, Ago Y, Hasebe S, Nishiyama S, Tanaka T, Oka S, Takuma K, Matsuda T;
    Involvement of prefrontal AMPA receptors in encounter stimulation-induced hyperactivity in isolation-reared mice.
    Int J Neuropsychopharmacol., In press.
  • Ago Y, Araki R, Tanaka T, Sasaga A, Nishiyama S, Takuma K, Matsuda T
    Role of social enconter-induced activation of prefrontal serotonergic system in the abnormal behavior of isolation-reared mice.
    Neuropsychopharmacology,8(8):1535-1547,2013.
  • Ago Y, Yano K, Araki R, Hiramatsu N, Kita Y, Kawasaki T, Onoe H, Chiaki S, Nakazato A, Hashimoto, Baba A, Takuma K, Matsuda T;
    Metabotropic glutamate 2/3 receptor antagonists improve behavioral and prefrontal dopaminergic alterations in the chronic corticosterone-induced depression model in mice.
    Neuropharmacology,65:29-38.2013.
  • Sekiya M, Kiyohara H, Maruyama H, Yabe T, Yamada H.
    Modulation of chemokine expression on intestial epithelial cells by Kampo(traditional Japanese herbal) medicine, Hochuekkito, and its active ingredients.
    J Nat Med.,67(3):626-635,2013.
  • Inatomi Y, Murata H, Inaba A, Nakatani T, Lang FA, Murata J, Iimura M;
    New glycosides of acetophenone derivatives and phenylpropanoids from Juniperus occidentails.
    J Nat Med., 67,359-368,2013.
  • 2012年
  • Ago Y, Araki R, Yano K, Kawasaki T, Chiaki S, Nakazato A, Onoe H, Hashimoto H, Baba A, Takuma K, Matsuda T;
    The selective metabotropic glutamate 2/3 receptor agonist MGS0028 reverses isolation rearing-induced abnormal behaviors in mice.
    J Pharmacol Sci., 118(2):295-298,2012.
  • Ito N, Hori A, Yabe T, Nagai T, Oikawa T, Yamada H, Hanawa T;
    Involvement of neuropeptode Y signaling in the antidepressant-like effect and hippocampal cell proliferation induced by kososan, a Kampo medicine, in the stress-induced depression-like model mice.
    Biol. Pharm. Bull., 35:1775-1783,2012.
  • Becerra SP, Dass CR, Yabe T, Crawford SE;
    Pigment epithelium-derived factor: chemistry,structurr,biology,and applications.
    J Biomed Biotechnol.,2012.
  • 2011年
  • Ago Y, Araki R, Yano K, Hiramatsu N, Kawasaki T, Chiaki S, Nakazato A, Onoe H, Hashimoto H, Baba A, Takuma K, Matsuda T;
    Activation of metabotropic glutamate 2/3 receptors attenuates methamphetamine-induceed hyperlocomotion and increase in prefrontal serotonergic neurotransmission.
    Psychopharmacology,217(3):443-452,2011.
  • Kawasaki T, Ago Y, Yano K, Araki R, Washida Y, Onoe H, Chiaki S, Nakazato A, Hashimoto H, Baba A, Takuma K, Matsuda T;
    Increased binding of cortical and hipopocampal group U metabotropic glutamate recepators in isolation-reard mice.
    Neuropharmacology,60(2-3):397-404,2011.
  • 2010年
  • Namba T, Yabe T, Gonda Y, Ichikawa N, Sanagi T, Arikawa-Hirasawa E, Mochizuki H, Kohsaka S, Uchino S:
    PEDF up-regulation induced by memantine,an NMDA receptor antagonist, is involved in increased proliferation of hipopocampal progenitor cells.
    Neuroscience,167:372-383,2010.
  • Yabe T, Hirahara H, Harada N, Ito N, Nagai T, Sanagi T, Yamada H;
    Ferulic acid induces neural progenitor cell proliferation in vitro and in vivo.
    Neuroscience,165(2)522-531,2010.
  • Sanagi T, Yabe T, Yamada H;
    Adenoviral gene delivery of pigment epithelium-derived factor(PEDF) protects striatal neurons from quinolinic acid-induced excitotoxicity.
    J.Neuropath. Exp.Neurol.,69:224-33,2010.
  • Yabe T, Sanagi T, Yamada H;
    The neuroprotective role of PEDF;Implication for the therapy of neurological disorders.
    Current Mol.Med.,10:259-266,2010.
  • Iida N, Inatomi Y, Murata H, Murata J, Lang FA, Tanaka T, Nakanishi T, Inada A;
    New phenylpropanoid glycosides from Juniperus communis var.depressa.
    Chem.Pharm.Bull.,58(5),742-746,2010.
  • 杉村康司、飯田修、香月茂樹、邑田裕子、稲富由香、飯田昭、南谷忠志、斉藤政美、岩渕久克、小野郁子;
    種子島および日南産タカクマムラサキの生育環境と精油成分の比較
    植物研究雑誌,85(2),90-98,2010.
  • 2009年
  • Ito N, Yabe T, Nagai T, Oikawa T, Yamada H, Hanawa T;
    A possible mechanism underlying an antidepressive-like effect kososan,a Kampo medicine,via the hypothalamic orexinergic system in the stress-induced depression-like model mice.
    Biol.Pharm Bull.,32(10)1716-1722,2009.
  • Inada A, Morimoto C, Yoshikawa T, Inatomi Y, Murata H;
    24-ethyl,24-methyl-29-nor-lanostanes from leaves of Freycinetia formosana.
    Chem.Pharm.Bull.,57(11),1303-1304,2009.
  • Inada A, Sayama M, Matsuo Y, Yamaguchi M, Inatomi Y, Murata H;
    Iridoido and fravonol glucosides from the leaves of Geniostoma glarum.
    生薬学雑誌, 63(2),56-57,2009.
  • 2008年
  • Ito N, Yabe T, Gamo Y, Nagai T, Oikawa T, Yamada H, Hanawa T;
    I.c.v.administration of orexin-A induces an antidepressive-like effect through hippocampal cell proliferation.
    Neuroscience,157(4):720-732,2008.
  • Murakami Y, Ikeda Y, Yonemitsu Y, Onimaru M, Nakagawa K, Kohno R, Miyazaki M, Hisatomi T, Nakamura M, Yabe T, Hasegawa M, Ishibashi T, Sueishi K;
    Inhibition of nuclear translocation of apoptosis-indecing factor is an essential mechanism of the neuroprotective activity of pigment epithelium-delived factor in a rat model of retinal degeneration.
    Am.J.Pathol.,173(5):1326-1338,2008.
  • Ito N, Yabe T, Gamo Y, Nagai T, Oikawa T, Yamada H, Hanawa T;
    Rosmarinic acid from Perillae Herba produces an antidepressant-like effect in mice through cell proliferation in the hippocampus.
    Biol.Pharm.Bull.,31(7)1376-1380,2008.
  • Sanagi T, Yabe T, Yamada H;
    Gene transfer of PEDF attenuates ischemic brain damage in the rat middle cerebral artery occlusion model.
    J.Neurochem.,106(4):1841-1854,2008.
  • Li L, Lundkvist A, Andersson D, Wihelmsson U, Nagai N, Pardo AC, Nodin C, Stahlberg A, Aprico K, Larson K, Yabe T,
    Moons L, Fotheringham A, Davies I, Carmeliet P, Schwartz JP, Pekna M, Kubista M, Blomstrand F, Maragakis N, Nilsson M, Pekny M:
    Protective role of reactive astrocytes in brain ischemia.
    J.Cerb.Blood.Flow.Metab.,28(3):468-481.2008.
  • Muto N, Tomokumi T, Haramoto M, Tatemoto H, Nakanishi T, Inatomi Y, Inada A;
    Isolation of apotosis-and differentiation-inducing substances toward human promyelocytic leukemia HL-60cells from leaves of Juniperus taxifolia.
    Biotechnology,and Biochemistry,72(2),477-484,2008.
  • Inada A, Ogasawara R, Koga I, Nakatani N, Inatomi Y, Murata H, Nishi M, Nakanishi T;
    Three new furoquinoline alkaloids from the leaves of Boninia glabra.
    Chem.Pharm.Bull.,56(5),727-729,2008.
  • 2007年
  • Sanagi T, Yabe T, Yamada H;
    Changes in pigment epithelium-derived factor expression following kainic acid induced cerebellar lesion in rat.
    Neurosci.Lett.,424(1):66-671,2007.
  • Iida N, Inatomi Y, Murata H, Inada A, Murata J, Lang FA, Matsuura N, Nakanishi T;
    A new flavone xyloside and two new flavan-3-ol glucosides from Junipers communis var. depressa.
    Chemistry & Biodiversity, 4(1),32-42,2007.
  • Nakanishi T, Inatomi Y, Murata H, Ishida S, Fujino Y, Miura K, Yasuno Y, Inada A, Lang FA, Nurata J;
    Triterpenes and flavonol glucuronoides from Oenothera cheiranthifolia.
    J.Murata,Chem.Pharm.Bull.,55(2),334-336,2007.
  • 2006年
  • Ito N, Nagai T, Yabe T, Nunome S, Hanawa T, Yamada H;
    Antidepressant-like activity of a Kampo(Japanese herbal)medicine, Kososan(Xiang-Su-San),and its mode of action via the hypothalamic-pituitary-adrenal axis.
    Phytomedicine,13:658-667,2006/
  • 2005年
  • Nakagawa T, Yabe T, Schwartz JP;
    Gene expression profiles of reactive astrocytes cultured from dopamine-depleted striatum.
    Neurobiology of Disease, 20:275-282,2005.
  • Takanohashi A, Yabe T, Schwartz JP;
    PEDF induces the production of chemokines by rat microglia.

    GLIA,51:266-278,2005
  • Sanagi T, Yabe T, Yamada H;
    The regulation of pro-inflammatory gene expression induced by pigment epithelium-delived factor in rat cultured microglial cells:involvement of NF-kB and CREB.
    Neurosci.lett.,380:105-110,2005.
  • Yabe T, Kanemitsu K, Sanagi T, Schwartz JP, Yamada H;
    Pigment epithelium-derived factor induces pro-survival genes through CREB and NF-kB activation in rat cultured cerebellar granule cells;Implication for its neuroprotective effect.
    Neuroscience,133:691-700,2005.
  • Yabe T, Sanagi T, Schwartz JP, Yamada H;
    Pigment epithelium-derived factor induces pro-inflammatory genes in neonatal astrocytes through activation of NF-kB and CREB.
    GLIA,50:223-234,2005.
  • Nagai T, Arai Y, Emori M, Nunome SY, Yabe T, Takeda T, Yamada H;
    Anti-allergic activity of a Kampo(Japanese herbal)medicine "Sho-seiryu-to(Xiao-Qing-Long-Tang)" on airway inflammation in a mouse model.
    Int Immunopharmacol.,4:1353-1365,2005.
  • Inada A, Ikeda Y, Murata H, Inatomi Y, Nakanishi T, Bhattacharyya K, Kar T, Bocelli G, Cantoni A;
    Unusual cycloanostanes from leaves of Pandanus boninensis.
    Phytochemistry,66(23),2729-2733,2005.
  • Inatomi Y, Iida N, Murata H, Inada A, Murata J, Lang FA, Iinuma M, Tanaka T, Nakanishi T;
    A pair of new atropisomeric cupressuflavone glucosides isolated from Juniperus var. depressa.
    Tetrahedron Lett.,46(38),6533-6535,2005.
  • Nakanishi T, Iida N, Inatomi Y, Murata H, Inada A, Murata J, Lang FA, Iinuma M, Tanaka T, Sakagami Y;
    A monoterpene glucoside and three megastigmane glycosides from Juniperus communis var. depressa.
    Chem. Pharm. Bull., 53(7),783-787,2005.
  • Furusawa M,Tanaka T,Ito T, Nakaya K, Iliya I,Ohyama M,Iimura M,Murata H,Inatomi Y,Inada A,Nakanishi T,Matsushita S, Kubota Y, Sawa R, Takahashi Y;
    Flavonol Glycosides in Leaves of Two Diospyros Species.
    Chem.Pharm.Bull.,53(5),591-593,2005.
  • Nakanishi T,Inatomi Y,Murata H,Shigeta K,Iida N,Inada A,Murata J,Farrera MAP,Iinuma M,Tanaka T,Oku N;
    A new and known cytotoxic aryltetralin-type lignans from stems of Bursera graveolens.
    Chem.Pharm.Bull.,53(2),229-231,2005.
  • 2004年
  • Yabe T,Herbert JT,Takanohashi A,Schwartz JP;
    Treatment of cerebellar granule cell neurons with the neurotrophic factor pigment epithelium-derived factor in vitro enhances expression of other neurotrophic factors as well as cytokines and chemokines.
    J Neuroscri Res.,77:642-652,2004.
  • Nakanishi T,Iida N,Inatomi Y, Murata H,Inada A,Murata J,Lang FA,Iinuma M,Tanaka T;
    New neolignan and pheylpropanoid glycosides in Juniperus communis var.depressa.
    Heterocycles,63(11),2573-2580,2004.
  • Nakanishi T,Iida N,Inatomi Y, Murata H,Inada A,Murata J,Lang FA,Iimura M,Tanaka Tk;
    Neolignan and flavonoid glycosides in Juniperus communis var.depressa.
    Phytochemistry,65,207-213,2004.
  • Tzourous M,Bigler L,Bienz S,Hesse M,Inada A,Murata H,Inatomi Y, Nakanishi T,Darnaedi D;
    Two new spermidine alkaloids from Chisocheton weinlandii.
    Helvetica Chimica Acta,87,1411-1425,2004.
  • 矢部武士、山田陽城;
    遠志と神経、
    Journal of Integrated medicine,15,443-445,2004.
  • 2003年
  • Yabe T,Tuchida H,Kiyohara H,Takeda T,Yamada H;
    Induction of NGF synthesis in astrocytes by onjisaponins of Polygala tenuifolia,constituents of kampo(Japanese herbal)medicine,Ninjin-yoei-to.
    Phytomedicine,10:106-114,2003
  • Furusawa M,Ito T,Nakaya K,Tanaka T,Ibrahin I,Iimura M,Murata H,Inatomi Y,Nakanishi T;
    Flavonol glycosides in two Diospyros plants and their radical scavenging activity.
    Heterocycles,60(11),2557-2563,2003.
  • Nakanishi T,Inatomi Y,Arai S,Yamada T,Fukatsu H,Murata H,Inada A,Matsuura N,Ubukata M,Murata J,Iinuma M,Farrea MAP,Tanaka T;
    New Luteolin 3'-O-acylated rhamnosides from leaves of Brusera graveolens.
    Heteocycles,60(9),2077-2083,2003.
  • 2002年
  • Yabe T,Samuels I,Schwartz JP;
    Bone morphogenetic proteins BMP-6 and BMP-7 have differential effects on survial and neurite outgrowth of cerebellar granule cell neurons.
  • Nakanishi T,Inatomi Y,Murata H,Iida N,Inada A,Lang FA,Murata J;
    Phytochemocal study on American plants I.Two new phenol glucosides,together with known biflavonones and diterpene,from leaves of Juniperus occidentalis Hook.
    Chem Pharm Bull,50(10),1358-1361,2002.
  • Inada A,Akiba T,Murata H,Inatomi Y,Nakanishi T,Darnaedi DA;
    New eudesmane sesquiterpene from the twigs of Aglaia grandis.
    Natural Medecines,56(4),147-149,2002.
  • Nitta T,Arai T,Takamatsu H,Inatami Y,Murata H,Tanaka T,Ito T,Nakanishi T;
    Antibacterial activity of extracts prepared from tropical and subtropical plants on methicillin-resistant Staphylococcus aureus.
    Journal of Health Science,48(3),273-276,2002.
  • 2001年
  • Yabe T,Wilson D,Schwartz JP;
    NF-kappaB activation is required for the neuroprotective effects of pigment epithelium-derived factor(PEDF) on cerebellar granule neurons.
    J Biol Chem.,276,43313-43319,2001.
  • Nomura T,Yabe T,Mochizuki H,Reiser J,Becerra SP,Schwartz JP;
    Survival Effects of pigment epithelium-derived factor(PEDF) expressed by a lentiviral vector in rat cerebellar granule cells.
    Der Neurosci.,23,145-152,2001.
  • Wu VW,Mo Q,Yabe T,Schwartz JP,Robinson SE;
    Perinatal opioids reduce striatal nerve growth factor content in rat striatum.
    Eur J Pharmacol.,2;414(2-3):211-4,2001.
  • Song QH,Toriizuka K,Iijima K,Yabe T,Yokozawa T,Cyong JC;
    Effects of hokoei-to(pugongying-tang),a Kampo formula,on monoamine content in brain regions and mitogenic activity of splenic lymphocytes in overiectomized mice.
    Am J Chin Med.,29,433-443,2001.
  • Suzuki T,Arai H,Iwasaki K,Tanii H,Higuchi M,Okamura N,Matsui T,Maruyama M,Yabe T,Toriizuka K,Yamada H,Hanawa T,Ikarashi Y, Sasaki H;
    A Japanese herbal medicine(Kami-Untan-to) in the treatment of Alzheimer's desease:A pilot study:
    Alzheimer's Reports,4,177-182,2001.
  • Piao ZF,Toriizuka K,Yabe T,Cyong JC;
    The effects of estradiol and Toki-shakuyaku-san(Tang-Kuei-Shao-Yao-San) on choline acetyltransferase activity,NGF,and NGF-mRNA in the brain regions of ovariectomized mice.
    J.Trad.Med.,18,210-216,2001.
  • Nagai T,Suzuki Y,Kiyohara H,Susa E,Kato T,Nagamine T,Hagiwara Y,Tamura S,Yabe T,Aizawa C,Yamada H;
    Onjisaponins,from the root of Polygalar tenuifolia WILLDENOW,as effective adjuvants for nasal infuluenza and jphtheria-pertussis vaccines.
    Vaccine,19,4824-4834,2001.
  • Song QH,Toriizuka K,Jin GB,Yabe T,Cyong JC;
    Long tern effects of Toki-shakuyaku-san on brain dopamine and nerver growth factor in olfactory-bulb-lesioned mice Jpn.
    J.Pharmacol.,86,183-8,2001.
  • Wada A,Tsutsumi M,Inatomi Y,Imai H,Shichida Y,Ito M;
    Retinoids and related compounds.Part 26.Synthesis of (11Z)-8,18-propano-and methano-retinals and conformational study of the rhodopsin chromophore.
    Jornal of the Chemical Society,Perkin Transactions1,19,2430-2439,2001.
  • Ito H,Nishitani E,Hatano T,Nakanishi T,Inada A,Murata H,Inatomi Y,Matsuura N,Ono K,Lanf FA,MUrata J,Yoshida T;
    Tannnins and related poluphenola,HIV reverse transcriptase inhibitors,from Rosa woodsii.
    Natural Medicines,55(4),218,2001
  • Sakagami K,Murata H,Nakanishi T,Inatomi Y,Watabe K,Iinuma N,Tanaka T,Murata J,Lang FA;
    Inhibitory effect of plant extracts on production of verotoxin enterohemorrhagic Escherichia coil O157:H7,
    Journal of Health Science,47,473-477,2001.
  • Inada A,Sorano T,Murata H,Inatomi Y,Darnaedi D,Nakanishi T;
    Diamide derivatives and cycloartanes from the leaves of Aglaia elliptica.
    Chem.Pharm.Bull.,49(9),1226-1228,2001.
  • 山田陽城、矢部武士;
    痴呆と加味温胆湯
    漢方と最新治療10,229-234,2001.
  • 2000年
  • Nomura T,Yabe T,Rosenthal ES,Krzan M,Schwartz JP;
    PSA-NCAM distinguishes reactive astrocytes in 6-OHDA-lesioned substantia nigra from those in the striatal terminal fields.
    J.Neurosci Res.,61,588-596,2000.
  • Wang Q,Iwasaki K,Suzuki T,Arai H,Ikarashi Y,Yabe T,Toriizuka K,Hanawa T,Yamada H,Sasaki H;
    Potentiation of brain acetylcholine neurons by Kami-Untan-To(KUT) in aged mice:implications for a possible antidementia drug.
    Phytomedicine,7,253-258,2000.
  • Yabe T,Yamada H,Shimomura M,Miyaoka H,Yamada Y;
    Induction of choline acetyltransferase activity in cholinergic neurons by stolonidiol:structure-activity relationship.
    J Nat Prod.,63,433-435,2000.
  • Toriizuka K,Hou P,Yabe T,Iijima K,Hanawa T,Cyong J;
    Effects of Kampo medicine, Toki-shikuyaku-san (Tang-Kuei-Shao-Yao-San), on choline acetultranseferase activity and norepinephrine contents in brain regions,and mitogenic activity of splenic lymphocytes in ovariectomized mice.
    J Ethnopharmacol.,71,133-143,2000.
  • Song QH,Toriizuka K,Iijima K,Yabe T,Yokozawa T,Cyong JC;
    Effects of Hokoei-to(Pu-gong-ying-tang),Kampo formula,on estradiol and progesterone contents in brain regions and serum in ovariectomized mice.
    J.Trad.Med.,17,180-185,2000.
  • Inatomi Y,Inada A,Murata H,Nishi M,Nakanishi T;
    Constituents of a fern,Diplazium subsinuatum V.Four new hopane-triterpene lactone glycosides.
    Chem.Pharm.Bull.,48(12),1930-1934,2000.
  • Inada A,Shino K,Murata H,Inatomi Y,Darnaedi D,Nakanishi T;
    Three putrescine biamides from the leaves of Aglaia grandis.
    Phytochemistry,53,1091-1095,2000.
  • 1998年
  • Yamada H and Yabe T;
    Anti-dementia actions of Kampo(Japanese-herbal) medicines.-Effects of Kampo medicines on central nervous system.
    Current Topics in Phytochemistry,1,157-168,1998.
  • Nakanishi T,Murata H,Inatomi Y,Inada A,Murata J,Lang FA,Yamasaki K,Nakano M,Kawahara T,Mori H,Otake T;
    Screening of anti-HIV-1 activity of north american plants.Activities of plant extracts,together with the components from Lethalia vulpina(L.) Hue,one of the extracts.
    Natural Medicines,52(6),1998.
  • Inada A,Iwahashi S,Yamaguchi I,Inatomi Y,Murata H,Nakanishi T,Darnaedi D,Nishino N,Tokuda H;
    Phytochemical studies on Mediaceous plants.XIII.Structures of constitunents of leaves of Aglaia odorata and their inhibitory effects on Epstein-barr virus activation.
    Natural Medicines,52(49),364-367,1998.
  • 1997年
  • Watanabe K,Yabe T,Itohara K,Toriizuka K and J-C.Cyong;
    Effects of traditional herbal medicines on the expression of 70kd heat shock protein (hsp 70) on IMR-32 cells.
    J.Trad Med.,14,157-162,1997.
  • Yabe T,Yamada H;
    Induction mechanism of nerve growth factor synthesis by Kami-untan-to;Role of cyclic AMP and c-fos mRNA accumulation.
    Phytomedicine.,4,191-198,1997.
  • Yabe T,Iizuka S,Komatsu Y,Yamada H;
    Enhancements of choline acetyltransferase activtty and nerve growth factor secretion by Polygalae Radix-extract containing active ingredients of Kami-untan-to.
    Phytomedicine,4,199-205,1997.
  • Nakanishi T,Inatomi Y,Nishi M,Murata H,Inada A;
    Constituents of a fern,Diplazium subsinuatum II.Structure elucidation of five new hopane-trierpene glycosides.
    Chem.Pharm.Bull.,45(1),8-12,1997.
  • Inada A,Ohtsuki S,Sorano T,Murata H,Inatomi Y,Darnaedi D,Nakanishi T;
    Cycloartane triterpenoids from Aglaia harmsiana.
    Phytochemistry,46(2),379-381,1997.
  • Inada A,Murata H,Inatomi Y,Nakanishi T,Darnaedi D;
    Pregnanes and triterpenoid hydroperoxides from the leaves of Aglaia grandis.
    Phytochemistry,45(6),1225-1228,1997.
  • 1996年
  • Yabe T and Yamada H;
    Kami-untan-to enhance choline acetyltransferase and nerve growth factor mRNA levels in brain cultured cells.
    Phytomedicine,3,361-367,1996/1997.
  • Yabe T,Toriizuka K and Yamada H;
    Kami-untan-to (KUT) improves cholinergic deficits in aged rats.
    Phytomedicine,2,253-258,1996.
  • Yoshida T,Ito H,Hatano T,Kurata M,Nakanishi T,Inada A,Murata H,Inatomi Y,Matsuura N,Ono K,Nakane H,Nada M,Lang FA;
    New hydrolyzable tannins,shephagenins A and B,from Shepherdia argentea as HIV-1 reverse transcriptase inhibitors.
    Chem.Pharm.Bull.,44(8),1436-1439,1996.
  • 矢部武士、山田陽城,
    気血水と漢方
    P & M Kampo,1,32-37,1996.
  • 1995年
  • Yabe T,Toriizuka K and Yamada H;
    Choline acetyltransferase activity enhancing effects of kami-untan-to(KUT) on basal forebrain cultured neurons and lesioned rats.
    Phytomedicine,2,41-46,1995.
  • Yabe T,Toriizuka K and Yamada H;
    effects of Kampo medicines on choline acetyltransferase activity in rat embryo septal cultures.
    J.trad.Med.,12,54-60,1995.
  • Inada A,Murata H,Inatomi Y,Nakanishi T,Darnaedi D;
    Cycloartane triterpenes fron the leaves of Aglaia harmsiana,
    J.Nat.Prod.,58(7),1143-1146,1995.
  • Wada A,Tsutsumi M,Inatomi Y,Imai H,Shichida Y,Ito M;
    Synthesis of 11Z-8,18-propano-and methano-retinals and their interaction with bovine opsin.
    Chem.Pharm.Bull.,43(8),1419-1421,1995.
  • Nakanishi T,Inatomi Y,Nishi M,Murata H,Inada A,Aibara S;
    Two new hopane-triterpene glycosides from a fern,Diplazium subsinuatum(Wall.Ex Hook.et Grev.)Tagawa.
    Chem.Pharm.Bull.,43(12),2256-2260,1995.
  • 1993年
  • Yabe T,Hashimoto H,Sekijima M,Degawa M,Hashimoto Y,Tashiro F and Ueno Y;
    Effects of nivalenol on hepatic drug-metabolizing activity in rats.
    Fd Chem Toxic,31,573-581,1993.
  • 1992年
  • Ueno Y,Yabe T,Hashimoto H,Sekijima M,Matsuda T,Kim DJ,Hasegawa R and Ito N;
    Enhancement of GST-P-positive liver cell foci developement by nivalenol a trichothecene mycotoxin.
    Carcinogenesis,13,787-791,1992.

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